Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

Author(s): Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone, Thibaud Coradin.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 3 , 2015

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Abstract:

The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.

Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2015
Page: [223 - 244]
Pages: 22
DOI: 10.2174/1568026614666141229112734
Price: $58

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