Objectives: Investigate the association between the chronic or occasional use of
nonsteroidal anti-inflammatory drugs (NSAIDs) and plasma levels of oxidative and inflammatory
markers in elderly at the Family Health Strategy in Brazil.
Methods: It was a cross-sectional study of data collected from random elderly volunteers. A
questionnaire including sociodemographic, health and medicine use data was administered. The
blood levels of FRAP (ferric reducing ability of plasma), AOPP (plasma advanced oxidation
protein products), MDA (malondialdehyde) and insulin were measured.
Results: The study sample comprised 758 elderly patients, of which 121 (15.96%) used NSAIDs.
The mean age was 68.53 years and 68.41 for individuals who used NSAIDs occasionally and
chronically, respectively. Gastric problems may be associated with the chronic or occasional use of
NSAIDs (P = 0.042). Which indicates mean plasma levels of Insulin and HOMA-IR (Homeostasis Model Assessment
Insulin Resistance) are increased in chronic use of NSAIDs and describes a statistical trend (P = 0.065) for the association
of chronic NSAIDs use with the BMI (body mass index) of the subjects studied.
Conclusion: This study suggests that there is no association between the chronic or occasional use of NSAIDs and
oxidative and inflammatory markers. It is known that NSAIDs have innumerable adverse effects, but they can have some
benefits. So, additional studies are needed to clarify whether NSAIDs are associated with these markers and whether they
are related with their real consequences.