Synthesis, Characterization and Microbial Activity of new Aryl esters of 1,1'-bis(4-hydroxyphenyl)cyclohexane
Chirag Bhupendra Patel,
Bhavin Babu Dhaduk,
Parsotam Hari Parsania.
Aryl esters of 1,1’-bis(4-hydroxyphenyl)cyclohexane (bisphenol-C) were synthesized by
condensing bisphenol-C with aryl acid chlorides using triethylamine as a catalyst and ethyl acetate as
a solvent at room temperature.The compounds were characterized by FTIR, 1HNMR, 13CNMR and
MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E.
coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus
MTCC-1323 and compared with standard drugs. The minimum inhibition concentration (MIC) of the
compounds was studied by micro broth dilution method. 1a-f and 2a-f showed moderate to comparable
antibacterial activity against E. coli, S.typhi, B. subtillis and S. aureus. All the compounds did not
show antifungal activity. Methyl side substituent and aromatic ring affected considerably antibacterial activity.
Keywords: Antibacterial activity, antifungal activity, bisphenols, spectral analysis, MIC.
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