A remarkable example of the progress in metal-free oxidation is the development of oxidation with dioxiranes.
The reactivity of these peroxides seems to be due to the tendency for easy electrophilic O-atom transfer to nucleophilic
substrates. This has been applied in order to achieve high regio- and stereoselective epoxidation and oxyfunctionalizations
of target molecules. This review addresses a new approach consisting of the application of homogeneous and heterogeneous
dioxiranes isolated and generate in situ.
This method has shown promise to contribute to resolving a well-recognized general problem in the organic synthesis to achieve efficient
synthetic methods that take into account the fundamental principles of green chemistry.
Keywords: Dioxirane, epoxidation, heterogeneous catalysis, homogeneous catalysis, metal free oxidation, target molecules.
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