Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives

Author(s): Ambareen Shaikh , Jyotsna S. Meshram .

Journal Name: Current Microwave Chemistry

Volume 2 , Issue 2 , 2015

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Abstract:

In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.

Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2015
Page: [166 - 172]
Pages: 7
DOI: 10.2174/2213335602666141217222008
Price: $58

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