In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone
derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were
characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened
for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro
anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological
assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides,
compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation
against the selected strains of bacteria.
Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.
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