Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction
Muhammad Asrar ul Haq,
David L. Hare,
Prevalence of Heart Failure with Preserved Ejection (HFPEF) has been rising steadily in the recent past.
Studies have shown that at least half of patients presenting with symptoms and signs of heart failure (HF) have preserved
left ventricular ejection fraction, i.e. HFPEF, and that this portion of the HF population consists predominantly of women,
older age group, and people with hypertension and other cardiovascular risk factors. The morbidity and mortality
associated with HFPEF are much higher than the normal population. Chronic hypertension is the most common cause in
addition to age, with suggestion of up to 60% of patients with HFPEF being hypertensive. Addressing the specific
aetiology and aggressive risk factor modification remain the mainstay in the treatment of HFPEF. Current guidelines
recommend the management should involve treatment of hypertension, control of heart rate, venous pressure reduction,
and prevention of myocardial ischemia. This review aims to discuss the role of hypertension in the pathophysiology, risk
stratification and prognosis of HFPEF, as well as the current available data on various antihypertensive options in this
Keywords: Heart failure, HFPEF, HFNEF, hypertension.
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