FeCl3/Ultrasound Mediated Reaction of 2-aminothiophenol with Aldehydes in Water: Synthesis of 2-substituted Benzothiazoles of Pharmacological Interest

Author(s): Ponasanapalli Tirumala Venkata Ankayya Srinivas, Sallagundla Bhavani, Dandela Rambabu, Mandava Venkata Basaveswara Rao, Ravikumar Kapavarapu, Manojit Pal.

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 6 , 2015

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

We report a FeCl3•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

Keywords: Benzothiazole, FeCl3, ultrasound, water, PDE4.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 6
Year: 2015
Page: [457 - 465]
Pages: 9
DOI: 10.2174/1570180812666141216211045
Price: $65

Article Metrics

PDF: 39
HTML: 2
EPUB: 1
PRC: 1