Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives

Author(s): Enise Ece Gurdal, Ebru Buclulgan, Irem Durmaz, Rengul Cetin-Atalay, Mine Yarim.

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Abstract:

Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI50 values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Aroyl substituted compounds 1h and 1j were found to be the most active derivatives. In addition, further investigation of compounds 1h and 1j by Hoechst staining and FACS revealed that these compounds cause apoptosis by cell cycle arrest at subG1 phase.

Keywords: Anticancer, apoptosis, benzothiazole, cytotoxicity, piperazine, sulphorhodamine B.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2015
Page: [382 - 389]
Pages: 8
DOI: 10.2174/1871520615666141216151101
Price: $58