There are numerous reports that show the benefits on the health attributed to the probiotic
consumptions. Most of the studies were performed using animal models and only some of them were
validated in controlled human trials. The present review is divided in two sections. In the first section we
describe how the probiotic microorganisms can interact with the intestinal epithelial cells that are the first line of cell in
the mucosal site, focusing in the studies of two probiotic strains: Lactobacillus casei DN-114001 (actually Lactobacillus
paracasei CNCMI-1518) and Lactobacillus casei CRL 431. Then we describe same beneficial effects attributed to
probiotic administration and the administration of fermented milks containing these microorganisms or potential probiotic
yoghurt, principally on the immune system and on the intestinal barrier in different experimental mouse models like
enteropathogenic infection, malnutrition, cancer and intestinal inflammation.
Keywords: Mucosal immunity, probiotic, probiotic claims, probiotic fermented milk, systemic immunity.
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