Tailoring Effect of Alkyl Chain Length and Counter Anion on Antimicrobial Behavior of 4–Vinyl Pyridine–based Cationic Polymers
Ghanshyam S. Chauhan,
Rajeev K. Sharma.
Polymers exhibiting anti–microbial properties constitute an important class of bioactive
polymers whose properties can be easily tuned by simple polymer analogous reactions. Two series of
new polymers were synthesized from 4–Vinyl pyridine, which was polymerized and quaternized in
situ by using alkyl bromides of varying alkyl chain length. The well–characterized polymers were
evaluated for their anti–microbial activity against a gram (–) bacterium (Citrobacter freundii) and fungus
(Mucor circinelloides), and penicillin and fluconazole were the respective references. Polymer that
exhibited the best activity was subjected to anion metathesis reactions as Br– was replaced with –OH, SO4
or CH3COO– to generate another series of new polymers. All the polymers exhibited strong antimicrobial activity against
both the microbes studied. Polymer having butyl alkyl chain and –OH as counter ion exhibited the strongest activity with
minimum inhibitory concentration of 60.0 µg/mL and 250 µg/mL, respectively, against the bacterium and fungus studied.
Keywords: Alkyl chain length, anion metathesis, antimicrobial polymers, minimum inhibitory concentration, structure– activity
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