Title:Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions
VOLUME: 2 ISSUE: 3
Author(s):Gyorgy Keglevich and Alajos Grun
Affiliation:Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.
Keywords:C-alkylation, CH-acidic compounds, green chemistry, microwave irradiation, phase transfer catalysis.
Abstract:In this minireview, the possible utilization of the microwave (MW) technique in solid–liquid
(S–L) phase C-alkylations is summarized. In the S–L phase C-alkylation of a series of simple active
methylene containing compounds, such as diethyl malonate, ethyl acetoacetate and ethyl cyanoacetate,
as well as P=O-containing derivatives, such as tetraethyl methylenebisphosphonate, diethyl
cyanomethylphosphonate and diethyl ethoxycarbonylmethylphosphonate, in most of the cases, there is
no need to use a phase transfer catalyst, as MW promotes the reaction in itself. Most of the Calkylations
was performed under solvent-free conditions. The elimination of the catalyst and solvent
from the system means an environmentally friendly (“green”) accomplishment.
