Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

Author(s): Concepcion Alonso, Maria Fuertes, Maria Gonzalez, Alicia Rodriguez-Gascon, Gloria Rubiales, Francisco Palacios.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 23 , 2014

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Graphical Abstract:


The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity against human colon cancer cells (COLO 205).

Keywords: Camptothecin, cytotoxicity, heterocycles, inhibitory activity, naphthyridines, topoisomerase I.

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Article Details

Year: 2014
Page: [2722 - 2728]
Pages: 7
DOI: 10.2174/1568026614666141215152441
Price: $58

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