Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Human Umbilical Cord Blood Cells and Diabetes Mellitus: Recent Advances

Author(s): Alluru S. Reddi, Neil Kothari, Kishore Kuppasani, Norman Ende.

Abstract:

Stem cell therapy for patients with diabetes is an area of great interest to both scientists and clinicians. Human umbilical cord blood cells (HUCBCs) are being increasingly used as a source of stem cells for cell-based therapy for diabetes because these cells can differentiate into pancreatic islet β-cells. Administration of HUCBCs has been shown to lower blood glucose levels in diabetic animal models. The use of autologous HUCBC transfusion in type 1 diabetic children has not shown any benefit. However, “Stem Cell Educator” therapy has shown promise in long term lowering of blood glucose levels in both type 1 and type 2 diabetic patients. In this review, we will briefly discuss recent advances in HUCBC therapy in the treatment of diabetes and some of its complications.

Keywords: β-cells, clinical trials, diabetes mellitus, differentiation, human umbilical cord blood, stem cells, stem cell educator therapy.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2015
Page: [266 - 270]
Pages: 5
DOI: 10.2174/1574888X10666141212122421
Price: $58