Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


Human Umbilical Cord Blood Cells and Diabetes Mellitus: Recent Advances

Author(s): Alluru S. Reddi, Neil Kothari, Kishore Kuppasani, Norman Ende.


Stem cell therapy for patients with diabetes is an area of great interest to both scientists and clinicians. Human umbilical cord blood cells (HUCBCs) are being increasingly used as a source of stem cells for cell-based therapy for diabetes because these cells can differentiate into pancreatic islet β-cells. Administration of HUCBCs has been shown to lower blood glucose levels in diabetic animal models. The use of autologous HUCBC transfusion in type 1 diabetic children has not shown any benefit. However, “Stem Cell Educator” therapy has shown promise in long term lowering of blood glucose levels in both type 1 and type 2 diabetic patients. In this review, we will briefly discuss recent advances in HUCBC therapy in the treatment of diabetes and some of its complications.

Keywords: β-cells, clinical trials, diabetes mellitus, differentiation, human umbilical cord blood, stem cells, stem cell educator therapy.

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Article Details

Year: 2015
Page: [266 - 270]
Pages: 5
DOI: 10.2174/1574888X10666141212122421
Price: $58