Epigenetic Regulation of Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and Therapy

Author(s): Jian -Qiu Wang, Kou -Juey Wu.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 10 , 2015

Abstract:

Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and its downstream transcriptional factors, is one of the most important mechanisms inducing epithelial-mesenchymal transition (EMT), which has been widely accepted as a crucial step to generate early stage of tumor metastasis. Accumulating evidence suggests that epigenetic mechanisms play important roles in hypoxia-induced EMT and metastasis. These epigenetic regulations are mediated by various players including chromatin modifiers, transcriptional co-regulators, microRNAs, etc. In this review, we discuss how his tone-modifying enzymes and transcriptional co-regulators regulate EMT under hypoxic conditions. Developed or potential anticancer agents targeting epigenetic molecules regulating hypoxia-induced EMT are also discussed.

Keywords: Epigenetic regulation, hypoxia, epithelial-mesenchymal transition, HIF-1α, chromatin modifier, co-regulator, target.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 21
ISSUE: 10
Year: 2015
Page: [1272 - 1278]
Pages: 7
DOI: 10.2174/1381612821666141211145610
Price: $58

Article Metrics

PDF: 45