Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is
extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology
brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development
and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition
(EMT), invasion, angiogenesis and upregulating Wnt/β-catenin signalling. Our recent experimental findings are also
summarized to prove that FoxM1 is a novel therapeutic target against GBM.
Keywords: Glioblastoma, tumorigenesis, EMT, invasion, angiogenesis, FoxM1, Wnt/β-catenin signaling.
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