Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor

Author(s): Zhongyong Wang, Sicong Zhang, Timothy L Siu, Suyun Huang.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 10 , 2015

Abstract:

Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition (EMT), invasion, angiogenesis and upregulating Wnt/β-catenin signalling. Our recent experimental findings are also summarized to prove that FoxM1 is a novel therapeutic target against GBM.

Keywords: Glioblastoma, tumorigenesis, EMT, invasion, angiogenesis, FoxM1, Wnt/β-catenin signaling.

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Article Details

VOLUME: 21
ISSUE: 10
Year: 2015
Page: [1268 - 1271]
Pages: 4
DOI: 10.2174/1381612821666141211115949
Price: $58

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