The Impact of Nandrolone Decanoate on the Central Nervous System

Author(s): Francesco P. Busardo, Paola Frati, Mariantonia Di Sanzo, Simona Napoletano, Enrica Pinchi, Simona Zaami, Vittorio Fineschi.

Journal Name: Current Neuropharmacology

Volume 13 , Issue 1 , 2015

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.

Keywords: Nandrolone decanoate (ND), Anabolic androgenic steroids (AAS), neurological effects, anxiety, aggression, learning and memory.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 1
Year: 2015
Page: [122 - 131]
Pages: 10
DOI: 10.2174/1570159X13666141210225822

Article Metrics

PDF: 27