To formulate an omeprazole buccal adhesive tablet with improved bioavailability using sodium
taurocholate, omeprazole buccal adhesive tablets were prepared with sodium alginate, HPMC, magnesium oxide and different
quantities of sodium taurocholate. Their physicochemical properties, such as the mucoadhesive force, stability in
human saliva and release, were examined. Moreover, the absolute bioavailability was assessed by comparing the buccal
administration to an omeprazole solution given intravenously to hamsters. Sodium taurocholate barely influenced the mucoadhesive
force of the tablets; however, it affected the drug stability in human saliva. It positively influenced the fast
drug release, but did not affect the release mechanism. In particular, omeprazole buccal adhesive tablets [omeprazole/
sodium alginate/HPMC/magnesium oxide/sodium taurocholate (20/24/6/50/10 mg/tab)] showed an absolute bioavailability
of about 30% in hamsters. They remained attached to the cheeks without disintegration. Moreover, they were stable
in human saliva for at least 4 h. Thus, it was concluded that this omeprazole buccal adhesive tablet could be a useful possible
commercial pharmaceutical product.
Keywords: Absolute bioavailability, enhancer, mucoadhesive force, omeprazole buccal adhesive tablet, sodium taurocholate,
stability in human saliva.
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