An Overview of Naturally Occurring Histone Deacetylase Inhibitors

Author(s): Bumki Kim, Jiyong Hong.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 24 , 2014

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Abstract:

Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.

Keywords: Epigenetics, Histone deacetylase inhibitor, Histone modification, Isoform selectivity, Natural product.

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Article Details

VOLUME: 14
ISSUE: 24
Year: 2014
Page: [2759 - 2782]
Pages: 24
DOI: 10.2174/1568026615666141208105614
Price: $58

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