Radiotherapy plays an essential primary role in cancer patients. Regardless of its significant advances
in treatment options, tumor recurrence and radio-resistance in cancer cells still occur in a high percentage
of patients. Furthermore, the over expression of miRNAs accompanies the development of radio-resistant cancer cells.
Consequently, miRNAs might serve as therapeutic targets for the treatment of radio-resistance in cancer cells. The findings
of the current research also signify that the use of a natural anti-miRNA substance could inhibit specific miRNAs,
and, concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy.
Therefore, in this review, we have reported the association of miRNAs with radio-resistance and the potential uses of
natural remedies as green gene therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation
on healthy cells during radiotherapy.
Keywords: Gene therapy, miRNAs, natural remedies, radioprotector, radioresistance, tumor recurrence.
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