An easy and convenient direct synthesis of 2-azetidinones is described. The [2+2] cycloaddition reaction of
imines and carboxylic acids using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) has
been employed to synthesize a variety of 2-azetidinones in high yields. The products were easily isolated because the byproducts
are highly soluble in water.
Keywords: β-Lactam, 2-Azetidinone, Staudinger reaction, DMTMM, Ketene, Imine.
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