Effects of Physical Exercise on Depressive Symptoms and Biomarkers in Depression

Author(s): Trevor Archer, Torbjorn Josefsson, Magnus Lindwall.

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 13 , Issue 10 , 2014

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Abstract:

Regular physical exercise/activity has been shown repeatedly to promote positive benefits in cognitive, emotional and motor domains concomitant with reductions in distress and negative affect. It exerts a preventative role in anxiety and depressive states and facilitates psychological well-being in both adolescents and adults. Not least, several meta-analyses attest to improvements brought about by exercise. In the present treatise, the beneficial effects of exercise upon cognitive, executive function and working memory, emotional, self-esteem and depressed mood, motivational, anhedonia and psychomotor retardation, and somatic/physical, sleep disturbances and chronic aches and pains, categories of depression are discussed. Concurrently, the amelioration of several biomarkers associated with depressive states: hypothalamic-pituitary-adrenal (HPA) axis homeostasis, anti-neurodegenerative effects, monoamine metabolism regulation and neuroimmune functioning. The notion that physical exercise may function as “scaffolding” that buttresses available network circuits, anti-inflammatory defences and neuroreparative processes, e.g. brain-derived neurotrophic factor (BDNF), holds a certain appeal.

Keywords: Biomarkers, cognition, depression, emotion, exercise, HPA-axis, monoamines, motivation, neurodegeneration, neuroimmune function, physical activity, somatic, symptoms.

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2014
Page: [1640 - 1653]
Pages: 14
DOI: 10.2174/1871527313666141130203245
Price: $58

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