In search of novel cytotoxic agents based on acridone scaffold, twenty five derivatives of acridone-2-
carboxamide were synthesized and evaluated against a panel of eleven cancer cell lines by using MTT assay.
Amides, A5 and A8 (IC50 = 0.3 µM) exhibited good cytotoxicity against MCF7. Compound A22 (IC50 = 4.3 µM)
was found to be selectively cytotoxic against cancer cell line MCF7 and KB403. Particularly, promising
cytotoxic activities were shown by amides A6 (IC50 = 0.7 µM), A16 (IC50 = 6.3 µM), A8 (IC50 = 0.9 µM ), A21
(IC50 = 1.3 µM), A5 (IC50 = 2.9 µM), A8 (IC50 = 2.8 µM), A14 (IC50 = 0.8 µM), A9 (IC50 = 0.8 µM) and A8 (IC50
= 0.4 µM) against cell lines; PA1, WRL68, CaCO2, TK-10, K-562, PC-3, HOP-92, ECV-304 and UACC-257,
respectively. The favorable cytotoxic profile and non-toxicity towards normal human cells displayed by the derivative revealed their
potential for further anticancer drug developments.