Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents
Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually.
Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β -
Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their
anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β -
carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their
chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.
Keywords: Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity
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