The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined
previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface
using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced
through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods,
such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics
that may be useful for pharmacological and diagnostic applications.
Keywords: Albumin, bioconjugation, biodistribution, chemical reaction, in vivo imaging, neoglycoprotein, N-glycans, tumor
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