Pyridazinone derivatives and their related analoges were introduced for gastric antiulcer and antisecretory
activities. Selected compounds were applied to ulcer models and showed their antiulcer and anti secretary activities. Some
pyridazinone compounds are recently reported as H3R antagonists. Some amine analogs of pyridazinones, pyridazinone–
phenethylamines and 4,5-fused pyridazinones showed histamine H3R antagonist activity with significant affinity for rat
and human H3R. These pyridazinone analogs also showed excellent selectivity and metabolic stability, with adequate
Keywords: Antiulcer, antagonist, antisecretory, histamine, H3 receptor, pyridazinones.
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