Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Poly(Ethylene Glycol) Amphiphilic Copolymer for Anticancer Drugs Delivery

Author(s): Runliang Feng, Wenxia Zhu, Fangfang Teng, Na Liu, Fengying Yang, Ning Meng, Zhimei Song.

Graphical Abstract:


Abstract:

Poly(ethylene glycol) is a water-soluble polymer. Due to its high safety and biocompatibility, it has been widely used to prepare amphiphilic copolymers for drug delivery. These copolymers can enhance water-solubility of hydrophobic drugs, improve their pharmacokinetic parameters and control their release from corresponding nanocarriers formed by its self-assembly. Anticancer drugs have some shortcomings such as lower water-solubility, bad targeting and some serious side-effects, which limit their applications and are dangerous to patients. So encapsulation of anticancer drugs into nanocarriers originated from its copolymeric derivates can improve their absorption, distribution, metabolism and excretion with better release properties and activities against cancer cells, increase their therapeutic effects, and realize their passive or active target delivery through structure modification. Recent research development of its drug delivery systems for anticancer drugs will be discussed.

Keywords: Amphiphilic copolymer, anticancer drugs, delivery, nanocarrier, Poly(ethylene glycol), review.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2015
Page: [176 - 188]
Pages: 13
DOI: 10.2174/1871520614666141124102347
Price: $58