There are numerous studies in the literature regarding the involvement of intestinal as well as extra
intestinal organs during the course of celiac disease, and there is accumulating evidence regarding the pancreatic changes
caused by this pathology. Method: The literature on the relationship between celiac disease and pancreatic involvement
has been extensively reviewed. Results: Exocrine pancreatic involvement regards both the function and the morphology
of the exocrine pancreas, and superimposed or more severe clinical changes seem to be related to the nutritional disturbances
caused by celiac disease or by the disease itself. Patients with celiac disease may also develop a chronic pancreatitis
more frequently than in general population both the intestinal and the extraintestinal manifestations of celiac disease.
Conclusions: Fecal elastase 1-determination in celiacs may be useful in detecting and curing exocrine pancreatic insufficiency
especially in patients with a new diagnosis of celiac disease or in those with refractory diarrhea. Few patents on
pancreatic extracts are also briefly described.
Keywords: Celiac disease, chronic pancreatitis, exocrine pancreatic insufficiency, extraintestinal manifestations pancreatic
extracts, refractory diarrhea.
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