Diabetes mellitus has been increasing rapidly worldwide, making it a huge health pressure on society in both
the developed and developing countries. During the last thirty years, diabetes mellitus, a chronic metabolic disease characterized
by hyperglycemia is proving itself to be fatal. Periodontitis was considered as one of the main, oral health problems
encountered in patients with diabetes mellitus. There exists a direct relation between the risk of complications of
diabetes and periodontitis over time. The present review gives an outline of the features that govern the interrelationship
between zinc and diabetes mellitus with periodontal disease, including the physiologic mechanisms and clinical studies,
and presents scientific evidences. The disturbance in the zinc micronutrient and increased oxidative stress in type 2 diabetes
may bring about insulin resistance and the creation of diabetic complications. The progression of diabetes mellitus
may bring about perturbation in micronutrient metabolism and status.
Keywords: Micronutrients, oxidative stress, periodontitis, tissue damage, type 2 diabetes mellitus, zinc.
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