Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Review of Procedures Used for the Extraction of Anti-Cancer Compounds from Tropical Plants

Author(s): Saurabh Pandey, Paul N. Shaw, Amitha K. Hewavitharana.

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Abstract:

Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin. The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).

Keywords: Anti-cancer, bio actives, drug discovery, extraction, tropical plants.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2015
Page: [314 - 326]
Pages: 13
DOI: 10.2174/1871520614666141114202104
Price: $58