Review of Procedures Used for the Extraction of Anti-Cancer Compounds from Tropical Plants
Paul N. Shaw,
Amitha K. Hewavitharana.
Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer
Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin.
The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for
the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer
compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to
the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis
of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were
PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).
Keywords: Anti-cancer, bio actives, drug discovery, extraction, tropical plants.
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