Aim: The authors aimed to show the possible relationship between keratoconjunctivitis sicca (KCS) and
Chlamydia pneumonia from the point of view of clinical and microbiological diagnostics. Material and Methods: 94
adult patients were treated for follicular conjunctivitis with symptoms of KCS with possible Chlamydia pneumoniae etiology.
The diagnosis of a chlamydial infection is based on the serological positivity of chlamydia antibodies and is further
based on the antigen positivity in conjunctival imprint preparations. Patients were treated with azithromycin for a period
of 12 days. Results: The reciprocal relationship between chlamydial infection and ocular symptoms was proved at 21 patients
(22%). Ninety% of patients showed positive anti-Chlamydia pneumoniae IgA and/or IgM with positivity in 80%,
including anti-LSP IgA and/or IgM antibodies. This finding was in correlation with the medium to strongly positive finding
of anti-cHSP60 IgG. In two patients, this infection was confirmed by the positivity of Chlamydia pneumoniae DNA in
peripheral leucocytes. The test group (100 healthy persons) showed 69% negative finding of anti-Chlamydia pneumoniae
antibodies or only positive anamnestic antibodies (IgG) and 31% positive antibodies IgA or IgM without clinical sings.
Conclusion: This study indicated the possible relationship between KCS and Chlamydia pneumoniae in the course of simultaneous
clinical signs of follicular conjunctivitis. KCS is a consequence of the action of local infection at the surface
of the conjunctiva. It also indicated the necessity of simultaneous evaluation of microbiological findings and the clinical
picture in consideration of overall antibiotic treatment in view of the high antibody background of Chlamydia pneumoniae
in the adult population in the Czech Republic. The authors aimed to show the possible relationship between the keratoconjunctivitis
sicca and Chlamydia pneumoniae based on results of the two studies. Some patents on conjunctivitis are also
briefly described in this article.
Keywords: Chlamydia pneumoniae, Chlamydia trachomatis, follicular conjunctivitis, keratoconjunctivitis sicca (KCS), microbiological
diagnostic, ocular discomfort.
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