Title:Biosynthetic Pathways to Glycosidase Inhibitors
VOLUME: 8 ISSUE: 1
Author(s):Fernando Gomollon-Bel, Ignacio Delso, Tomas Tejero and Pedro Merino
Affiliation:Laboratorio de Sintesis Asimetrica, Departamento de Sintesis y Estructura de Biomoléculas, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Facultad de Ciencias, Universidad de Zaragoza-CSIC, Campus San Francisco, 50009 Zaragoza, Aragon, Spain.
Keywords:Biosynthesis, deoxynojirimycin, glycosidase inhibitors, nojirimycin, swainsonine.
Abstract:Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including
N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring
glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses
on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles
including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and
transglycosidases.
