Biosynthetic Pathways to Glycosidase Inhibitors

Author(s): Fernando Gomollon-Bel, Ignacio Delso, Tomas Tejero, Pedro Merino.

Journal Name: Current Chemical Biology

Volume 8 , Issue 1 , 2014

Abstract:

Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases.

Keywords: Biosynthesis, deoxynojirimycin, glycosidase inhibitors, nojirimycin, swainsonine.

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2014
Page: [10 - 16]
Pages: 7
DOI: 10.2174/221279680801141112094818

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