18 chromone derivatives were designed and synthesized from paeonol. All synthetic compounds
were evaluated for their anti-proliferative activity towards eight human cancer cell lines including
HepG2, HL-60, KB, LLC, LNCaP, LU-1, MCF7, and SW480. Compounds 3g and 3h presented
the best cytotoxic effects towards tested cancer cell lines except HepG2. Their IC50 values were
ranging from 7.9±0.4 to 18.9±1.3 μg/mL. Meanwhile, compound 3l showed selective cytotoxicity
against MCF7 and KB with IC50 of 13.7±0.6 and 15.5±0.9 μg/mL, respectively.
Keywords: Anti-cancer activity, Imidazolidin-4-one, 7-Methoxychromone, Paeonol, Pyrimidine-2, 4, 6(1H, 3H, 5H)-trione,
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