Modulation of Renin-Angiotensin System and Arterial Stiffness: Evidence from Clinical Trials
Il Suk Sohn,
Arterial stiffness has been recognized as an independent risk factor for cardiovascular morbidity and mortality
in hypertension. The activity of the renin-angiotensin system(RAS) is well-known to be involved in the control of blood
pressure, and pathogenesis and evolution of several cardiovascular diseases. Although data relating the RAS activity to
arterial stiffness are incomplete, there is growing evidence which shows that drugs which interfere with angiotensin II
reduce arterial stiffness. This brief review is to summarize the various effects of commonly used antihypertensive agents
on arterial stiffness and to present clinical trials regarding RAS modulation in stiffness reduction.
Keywords: Arterial stiffness, cardiovascular disease, clinical trias, hypertension, rennin-angiotensin system.
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