Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine


Modulation of Renin-Angiotensin System and Arterial Stiffness: Evidence from Clinical Trials

Author(s): Il Suk Sohn, Chong-Jin Kim.


Arterial stiffness has been recognized as an independent risk factor for cardiovascular morbidity and mortality in hypertension. The activity of the renin-angiotensin system(RAS) is well-known to be involved in the control of blood pressure, and pathogenesis and evolution of several cardiovascular diseases. Although data relating the RAS activity to arterial stiffness are incomplete, there is growing evidence which shows that drugs which interfere with angiotensin II reduce arterial stiffness. This brief review is to summarize the various effects of commonly used antihypertensive agents on arterial stiffness and to present clinical trials regarding RAS modulation in stiffness reduction.

Keywords: Arterial stiffness, cardiovascular disease, clinical trias, hypertension, rennin-angiotensin system.

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Article Details

Year: 2014
Page: [37 - 40]
Pages: 4
DOI: 10.2174/157340211001141111160311