Revisiting the J-curve Phenomenon. An Old New Concept?
Daniel Medeiros Moreira,
Milton Ricardo Poffo,
Sulyane Matos De Menezes Alves,
Ademilson Rogerio Ferreira,
Erlon Oliveira de Abreu-Silva.
Cohort studies have demonstrated the association between blood pressure and increased
cardiovascular events. There are different therapeutic strategies to achieve goals of systolic and diastolic blood
pressure. For a long time, therapeutic targets were not well defined and the concept of "smaller is better" was
used diffusely. However, clinical trials have shown the presence of a "J-curve" in different clinical situations:
below a certain level of blood pressure, more aggressive reductions may not represent benefit and increase the
incidence of adverse events in elderly patients, patients with coronary artery disease, patients with diabetes or
chronic renal failure.
Keywords: Cardiovascular disease, cardiovascular risk, blood pressure, hypertension, hypertension treatment, j-curve.
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