Current Organocatalysis

Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, Texas
USA

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L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

Author(s): K. Srinivas, Naresh Kumar Katari, P. Satya Karuna, M.S. Surendra Babu.

Graphical Abstract:


Abstract:

L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Keywords: 2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2015
Page: [44 - 50]
Pages: 7
DOI: 10.2174/2213337201666141110222400