L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes
Naresh Kumar Katari,
P. Satya Karuna,
M.S. Surendra Babu.
L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2-
nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3-
carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The
isolation procedure is quiet easy and products recovered without further purification.
Keywords: 2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.
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