Lycium barbarum polysaccharide (LBP) has traditionally been used in Chinese medicine as
a chief ingredient of Lycium barbarum (wolf berry/goji berry) for the treatment of various diseases with the
symptoms of frequent drinking and urination. This study was conducted as a randomized, controlled
clinical trial. A total of 67 patients with type 2 diabetes (30 in control group and 37 in LBP group) were enrolled in this
prospective, randomized, double-blind study (administration at 300mg/day body weight). In order to observe the hypoglycemic
and lipid-lowering activity of LBP in patients with type 2 diabetes after dinner, various tests were conducted between
control and LBP intervention groups in 3 months. Although, the study had small sample size and short follow-up,
significant findings were observed. The results of our study indicated a remarkable protective effect of LBP in patients
with type 2 diabetes. Serum glucose was found to be significantly decreased and insulinogenic index increased during
OMTT after 3 months administration of LBP. LBP also increased HDL levels in patients with type 2 diabetes. It showed
more obvious hypoglycemic efficacy for those people who did not take any hypoglycemic medicine compared to patients
taking hypoglycemic medicines. This study showed LBP to be a good potential treatment aided-agent for type 2 diabetes.
Keywords: Lycium barbarum polysaccharide, type 2 diabetes, glucose, lipids, cytokines.
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