Stem cell-based therapies are considered as a promising treatment for many clinical usage
such as tooth regeneration, bone repairation, spinal cord injury, and so on. However, the ideal stem
cell for stem cell-based therapy still remains to be elucidated. In the past decades, several types of
stem cells have been isolated from teeth, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous
teeth (SHED), periodontal ligament stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs) and stem
cells from apical papilla (SCAP), which may be a good source for stem cell-based therapy in certain disease, especially
when they origin from neural crest is considered. In this review, the specific characteristics and advantages of the adult
dental stem cell population will be summarized and the molecular mechanisms of the differentiation of dental stem cell
during tooth development will be also discussed.
Keywords: Cell differential, dental follicle progenitor cells (DFPCs), dental pulp stem cells (DPSCs), molecular mechanisms,
periodontal ligament stem cells (PDLSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from apical
papilla (SCAP), tooth development.
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