Tablet Scoring and its Regulatory Perspective
V. Yugender Reddy,
T.M. Pramod Kumar.
The objective of this paper is to provide insight and better understanding of the regulations for the scored tablet
in regulated markets and World Health Organization. Splitting of tablets is done for various reasons; but is associated with
certain problems such as inaccurate split resulting in change of dose, enhanced drug degradation due to atmospheric exposure,
change in dissolution rate and extent. The accuracy of split is not uniform even with the use of commercial tablet
cutters. Often patients with impaired vision, and lack of skilled experience have difficulty during splitting tablets. Accurate
dosing may not be possible with splitting of tablets, especially with potent drugs. Tablet splitting may reduce the cost
of therapy and may accommodate dose changes as required, but impact on the overall quality of medication used in therapy.
Keywords: Dissolution, score, splitting, tablet.
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