Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Author(s): Yasir Arfat, Wei-Zhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Ge Zhang, Salman Iftikhar, Peng Shang, Tuan-Ming Yang, Ai-Rong Qian.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 6 , 2015

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Abstract:

Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

Keywords: Bone disorder, microRNAs, osteoblasts differentiation, signaling pathways.

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Article Details

VOLUME: 22
ISSUE: 6
Year: 2015
Page: [748 - 758]
Pages: 11
DOI: 10.2174/0929867321999141106121227
Price: $58

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