Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse
biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies
suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional
regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling.
Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The
differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling
pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be
associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation
and emphasizes their potential therapeutic role in metabolic bone disorders.
Keywords: Bone disorder, microRNAs, osteoblasts differentiation, signaling pathways.
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