A Review of Intrahepatic Cholestasis of Pregnancy
Christopher M. Tarney,
Intrahepatic cholestasis of pregnancy (ICP) is a gestational liver disease characterized by pruritus with
abnormal bile acids and an increased risk for adverse fetal outcomes. The etiology is unclear, but it believed to have
genetic, hormonal, and environmental components. Possible fetal complications include meconium staining of amniotic
fluid, preterm labor, and unexplained sudden intrauterine demise. Researchers are currently investigating multiple
different medications for the management of ICP. This article will review the epidemiology, clinical features, pregnancy
complications, and treatment for ICP. Furthermore, this review will discuss current recommendations on the timing of
delivery to mitigate possible fetal repercussions of this disease.
Keywords: Bile acids, intrahepatic cholestasis of pregnancy, ursodeoxycholic acid.
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