Anti-Angiogenesis Drug Discovery and Development

Volume: 2

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The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of ...
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Development of Novel Anti-Cancer Strategies Based on Angiogenesis Inhibition

Pp. 147-190 (44)

Rajiv P. Gude, Prachi Patil, Mohammad Zahid Kamran and Peeyush N. Goel

Abstract

Angiogenesis is the formation of new blood vessels from the pre-existing ones. It forms the core of the metastatic cascade, since the tumor cells needs nutrition for their growth at distant sites. The work by Folkman et al., has led to a significant understanding of the angiogenesis process and development of novel anti-cancer strategies based on angiogenesis inhibition. In the present chapter we have discussed various pro-angiogenic and anti-angiogenic molecules that are involved in angiogenesis. Further, we have tried to summarise the various molecules both natural and synthetic that inhibit angiogenesis and are being used as novel strategies for the treatment of cancer.

Keywords:

Angiogenesis, angiogenic switch, cancer, endothelial cells, growth factors, hypoxia, integrins, metastasis, natural inhibitors, signaling pathway, STAT-3, synthetic inhibitors, targeting, VEGF.

Affiliation:

Gude Lab, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi-Mumbai, India.