Tubulin represents a potent target in cancer chemotherapy. Combretastatin is a naturally occurring well known tubulin polymerization
inhibitor. Combretastatin and its analogues have been discussed in this review in detail. For better understanding, this review is
subdivided as per the carbon distance between to the two aromatic rings. Under these heading, various synthetic analogues, general synthetic
route, their brief SAR and structures of the most potent compound has been discussed. This article will be a good platform to guide
the chemist to design and synthesize drug like molecules for tubulin polymerization inhibitory potential with optimized pharmacokinetic
Keywords: Anticancer, antiproliferative, combretastatin analogues, combretastatin, microtubule binding agents, tubulin binding agents.
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