Gut-microbiota (GM) is considered a hidden metabolic organ of the human body, providing biochemical
pathways which are absent in the host. Balanced diet with calorie restriction (CR) promotes growth of healthy microbiota,
leading to longevity by down-regulating inflammatory responses. While, dysbiosis leads to body dysfunction, inducing
metabolic disorders, causing poor epithelial architecture, and impeding the development of mucosal-associated lymphoid
tissue, resulting in with reduced T and B cell populations, rendering the body prone to infections, cancer and allergy. The
GM enzymes activity is a new risk factor for cancer while gut-derived interleukin-6 is associated with hepatocellular
carcinoma development. GM can also influence the brain biochemistry and emotional behavior. The altered GM affects
the genes involved in second messenger pathway and long-term potentiation, leading to their differential expression in the
hippocampus, cortex, striatum and cerebellum. In addition, the dysbiotic GM is associated with autistic disorder. Living
with dysbiotic GM is possible with consequences of serious impairments.
Keywords: Allergy, cancer, gut-microbiota, metabolism, immunity, heart diseases, nervous system.
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