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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthesis of Pyrido- and Pyrimido-Fused Heterocycles by Multi-Component Reactions (Part 3)

Author(s): Ahmed H.M. Elwahy and Mohamed R. Shaaban

Volume 11, Issue 6, 2014

Page: [835 - 873] Pages: 39

DOI: 10.2174/157017941106141023114039

Price: $65

Abstract

Heterocycles constitute the largest diversity of organic molecules of chemical, biomedical, and industrial significance. They widely exist in numerous natural products, such as vitamins, hormones, antibiotics, alkaloids, herbicides, and dyes. They are also among the most frequently encountered scaffolds in numerous drugs and pharmaceutically relevant substances. This review highlights some remarkable achievements made recently in the application of multicomponent reactions (MCRs) to the design of pyrido- and pyrimidofused heterocycles by multi-component reactions that have appeared in the last ten years. MCRs reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy as well as manpower. Moreover, the reaction period can be substantially shortened.

Keywords: Fused heterocycles, metal catalyst, microwave, multicomponent reactions, pyridine, pyrimidine.

Graphical Abstract

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