Current Nanoscience

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Superior Cell Adhesion and Antithrombogenicity Supported by N+-bombarded Carbon Nanotubes

Author(s): M.L. Zhao, X.Q. Liu, Y. Cao, D.J. Li, H.Q. Gu.

Graphical Abstract:


Abstract:

Super hydrophilic multi-walled carbon nanotubes (MWCNTs) were bombarded by N ions through ion beam assisted deposition. MWCNTs were synthesized via chemical vapor deposition. Biological tests in vitro were performed on raw MWCNTs and N+-bombarded MWCNTs. Cellular adhesion was investigated both using human endothelial cells and mouse fibroblast cells. Results showed that N+-bombarded MWCNTs stimulated cell growth and proliferation, revealing superior cell adhesion. Antithrombogenicity of raw and N+-bombarded MWCNTs was evaluated by platelet conglutination, hemolysis and kinetic-clotting assays. Compared with raw MWCNTs, N+-bombarded MWCNTs displayed better morphology of platelets and red blood cells, longer kinetic blood-clotting time, which increased their thromboresistance, further antithrombogenicity.

Keywords: antithrombogenicity, cell adhesion, ion beam assisted deposition, Multi-walled carbon nanotubes, N+-bombarded multi-walled carbon nanotubes, .

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [135 - 142]
Pages: 8
DOI: 10.2174/1573413710666141021235558
Price: $58