Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy

Author(s): Kaniyampadi S. Snima, Prathesha Pillai, Aleena M. Cherian, Shantikumar V. Nair, Vinoth-Kumar Lakshmanan.

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Abstract:

Metformin, a biguanide, is a commonly administered drug for the management of type 2 diabetes mellitus. The drug received tremendous recognition, when retrospective studies proved metformin-associated reduction in cancer risk. Metformin has potential anticancer effects and an ability to suppress tumor growth both in vitro and in vivo. Activation of LKB1/AMPK pathway and cancer stem cell destruction along with cell cycle arrest and apoptosis induction are the proposed mechanisms of anticancer potential of metformin. Nanotechnology approaches have also been adopted for metformin delivery to cancer cells. This review directs on the application of metformin for the therapy of various cancers and also the different pathways responsible for the metformin derived anticancer effect. It also focuses on the pharmacological applications of metformin and the nanotechnology approaches for metformin delivery.

Keywords: Breast cancer, endometrial cancer, metformin, nanotechnology, prostate cancer, ovarian cancer, pancreatic cancer, pathways.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2014
Page: [727 - 736]
Pages: 10
DOI: 10.2174/1568009614666141020105502
Price: $58