MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review
Robert A. Smith,
Alfred K.-Y. Lam.
Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of
many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory
effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its
members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis,
apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and
methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as
prognostic markers and therapeutic targets in human cancers.
Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.
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