Amelioration of Cisplatin Induced Nephrotoxicity by Standardized Methanolic Extract of Roots of Boerhaavia diffusa
Bowlekar P. Babu,
Gadgoli C. Harihar.
In the present study, the methanolic extract of roots of B. diffusa was standardized for the isolated phenolic
aglycone (BD1) through HPTLC analysis and the content of BDE1 in the extract was found to be 5.755% w/w. The
extract was studied for its nephroprotective and nephrocurative effects in cisplatin (10 mg/kg b.w.i.p.) induced
nephrotoxicity in albino rats. Nephrocurative and nephroprotective potential of BDE was evaluated by monitoring the
parameters serum urea, createnin, blood urea nitrogen and antioxidant parameters like lipid peroxidation, super oxide
dismutase (SOD), catalase and NO scavenging activities. Treatment with single dose of Cisplatin led to significant
(P<0.001) increase in the values of blood urea, serum createnine and blood urea nitrogen. These elevated values were
found to be significantly (P<0.001) reduced and the levels of antioxidant parameters viz. superoxide dismutase, Catalase,
Lipid peroxidation and nitric oxide levels, were found to be equivalent to healthy animals due to treatment with 300
mg/kg b.w.p.o of the BDE. The results are also supported with the histopathological studies on kidneys.
Keywords: Antioxidants, Boerhaavia diffusa, cisplatin, nephrotoxicity.
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