Stem Cell Therapies for Ischemic Cardiovascular Diseases
Colin E. Murdoch,
Sophie A. Broadway-Stringer,
Elena De Falco.
Myocardial infarction results in loss of cardiac muscle and deficiency in cardiac performance. Likewise, peripheral
artery disease can result in critical limb ischemia leading to reduced mobility, non-healing ulcers, gangrene and
amputation. Both of these common conditions diminish quality of life and enhance risk of mortality. Successful advances
in treatment have led to more people surviving incidences of myocardial infarction or living with peripheral artery disease.
However, the current treatments are inadequate in repairing ischemic tissue. Over the last 5 years, a vast number of patents
have been submitted concerning the use of stem cells, which correlates with the exponential growth in stem cell publications.
Exploiting stem cell therapy offers a real potential in replacing ischemic tissue with functional cells. In this paper,
we review recent patents concerning stem cell therapy that have the potential to provide or potentiate novel treatment
for ischemic cardiovascular disease. In addition, we evaluate the promise of the inventions by describing some clinical trials
that are currently taking place, as well as considering how current research on ischemic cardiovascular disease may
change the patent landscape in the future.
Keywords: Cardiovascular, cell therapy, heart, ischemia, regenerative medicine, stem cells.
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