Abstract
Curcumin (β-diketones diferuloylmethane), a biphenolic compound of Curcuma longa is reported to elicit a plethora of health protective effects. The present study was carried out to investigate the in vivo protective effect of curcumin (340 mg/kg b.w., oral) against HgCl2 induced oxidative stress in wistar rats. PON1 arylesterase activity, -SH value, and LDL oxidation susceptibility were determined in plasma of control, control+ curcumin, control+ HgCl2, HgCl2+ curcumin treated rats. Oxidative stress down-regulated PON1 activity, decreased -SH value and increased LDL oxidation susceptibility in plasma. Curcumin treatment significantly (p<0.05) increased PON1 activity, -SH value and reduced LDL oxidation susceptibility in healthy and HgCl2 treated rats. We show that curcumin protects PON1 activity, -SH value and LDL oxidation, and hypothesize that its supplementation may lower the incidence of those diseases where reduced PON1 activity and higher LDL oxidation is reported.
Keywords: Curcumin, LDL oxidation, oxidative stress, plasma, PON1, thiol (-SH).
Letters in Drug Design & Discovery
Title:Role of Curcumin in Modulating Plasma PON1 Arylesterase Activity and Susceptibility to LDL Oxidation in Oxidatively Challenged Wistar Rats
Volume: 12 Issue: 4
Author(s): Prabhakar Singh and Syed Ibrahim Rizvi
Affiliation:
Keywords: Curcumin, LDL oxidation, oxidative stress, plasma, PON1, thiol (-SH).
Abstract: Curcumin (β-diketones diferuloylmethane), a biphenolic compound of Curcuma longa is reported to elicit a plethora of health protective effects. The present study was carried out to investigate the in vivo protective effect of curcumin (340 mg/kg b.w., oral) against HgCl2 induced oxidative stress in wistar rats. PON1 arylesterase activity, -SH value, and LDL oxidation susceptibility were determined in plasma of control, control+ curcumin, control+ HgCl2, HgCl2+ curcumin treated rats. Oxidative stress down-regulated PON1 activity, decreased -SH value and increased LDL oxidation susceptibility in plasma. Curcumin treatment significantly (p<0.05) increased PON1 activity, -SH value and reduced LDL oxidation susceptibility in healthy and HgCl2 treated rats. We show that curcumin protects PON1 activity, -SH value and LDL oxidation, and hypothesize that its supplementation may lower the incidence of those diseases where reduced PON1 activity and higher LDL oxidation is reported.
Export Options
About this article
Cite this article as:
Singh Prabhakar and Rizvi Ibrahim Syed, Role of Curcumin in Modulating Plasma PON1 Arylesterase Activity and Susceptibility to LDL Oxidation in Oxidatively Challenged Wistar Rats, Letters in Drug Design & Discovery 2015; 12 (4) . https://dx.doi.org/10.2174/1570180811666141016000539
DOI https://dx.doi.org/10.2174/1570180811666141016000539 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Pharmacologic Management of Pediatric Heart Failure in Congenital Heart Disease
Current Vascular Pharmacology Can microRNAs be Biomarkers or Targets for Therapy of Ischemic Coronary Artery Disease in Metabolic Syndrome?
Current Drug Targets Reduction of Sodium Intake is a Prerequisite for Preventing and Curing High Blood Pressure in Hypertensive Patients - Second Part: Guidelines
Current Hypertension Reviews Vitamin D Biology in Heart Failure: Molecular Mechanisms and Systematic Review
Current Drug Targets Autophagy Inhibition Rescues Against Leptin-Induced Cardiac Contractile Dysfunction
Current Pharmaceutical Design Pharmacotherapy for Obesity
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Vascular Disease and Insulin-Like Growth Factor-1
Vascular Disease Prevention (Discontinued) Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States
Current Pharmaceutical Design Human Amniotic Fluid Stem Cells as an Attractive Tool for Clinical Applications
Current Stem Cell Research & Therapy Heat Shock Protein-60 and Risk for Cardiovascular Disease
Current Pharmaceutical Design Critical Questions for Preclinical Trials on Safety and Efficacy of Vascular Endothelial Growth Factor-Based Therapeutic Angiogenesis for Ischemic Stroke
CNS & Neurological Disorders - Drug Targets Pentraxins and Atherosclerosis: The Role of PTX3
Current Pharmaceutical Design Treatment of Chronic Myeloid Leukemia Elderly Patients in the Tyrosine Kinase Inhibitor Era
Current Cancer Drug Targets Evidence on the Protective Role of High-Density Lipoprotein (HDL) in HIV-Infected Individuals
Current Vascular Pharmacology Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Current Psychiatry Reviews Statins and Alkylphospholipids as New Anticancer Agents Targeting Lipid Metabolism
Anti-Cancer Agents in Medicinal Chemistry Analysis of QTc Interval during Levofloxacin Prescription in Cardiac Patients with Pneumonia
Current Drug Safety Cellular Mechanisms of the Protective Effect of Polyphenols on the Neurovascular Unit in Strokes
Cardiovascular & Hematological Agents in Medicinal Chemistry N-Containing Ag(I) and Hg(II) Complexes: A New Class of Antibiotics
Current Topics in Medicinal Chemistry